Opportunity Information: Apply for W81XWH 22 TBIPHRP PCRA
The DoD Traumatic Brain Injury and Psychological Health, Patient-Centered Research Award (FY22 TBIPHRP PCRA; Funding Opportunity Number W81XWH-22-TBIPHRP-PCRA) is a Department of Defense funding opportunity designed to push proven or promising TBI and psychological health advances closer to real-world use. The central goal is to narrow the long-standing gap between what research shows can work and what actually gets adopted in clinics, health systems, and communities. Rather than focusing on early-stage discovery, this award emphasizes practical, patient-centered evidence about how to deploy interventions, clinical practices and guidelines, tools, and even policies so they reach the right populations at the right time and place, and lead to measurable patient benefit.
A defining feature of this program is its focus on implementation and real-world effectiveness. The DoD is looking for studies that build a knowledge base on dissemination, implementation, scale-up, sustainability, and appropriate use (or discontinuation) of clinical approaches relevant to TBI and psychological health. The opportunity supports clinical research and clinical trials only, meaning the work must be grounded in human-focused research. Preclinical studies and animal research are not allowed under this mechanism. Applicants may propose prospective or retrospective studies that involve human participants, human data or records, and/or human anatomical substances, but the program explicitly does not allow studies that require an Exception From Informed Consent (EFIC), which typically applies in certain emergency research situations.
The kinds of projects that fit this award are broad but clearly oriented toward patient-relevant outcomes and real-world decision-making. Competitive proposals may include comparative effectiveness research that weighs the benefits and harms of emerging or established interventions in routine care settings, where real patients and real constraints affect results. The award also supports development and testing of strategies to overcome barriers that keep evidence-based tools, policies, and guidelines from being adopted, adapted appropriately, integrated into workflows, expanded to larger populations, or sustained over time. In addition, applicants can analyze existing datasets or resources to inform clinical practice, refine or modify established clinical tools so they better fit the intended population or care environment, or evaluate existing tools with an eye toward improving outcomes that matter to patients. Notably, the scope also includes "de-implementation" research, meaning studies that identify when and why it is appropriate to stop or reduce the use of interventions, tools, or guidelines that are ineffective, unproven, low-value, or potentially harmful.
Several requirements shape how applicants must design their studies. The program mandates the use of Community-Based Participatory Research (CBPR) approaches in both development and execution of the proposed clinical research or trial, reinforcing that affected communities and stakeholders should meaningfully help shape the research questions, methods, and conduct of the work. These CBPR elements must be documented in specific application attachments (Attachments 11 and 12). Applicants must also include preliminary data that directly supports the feasibility or rationale of the proposed clinical research or trial. Where relevant, proposals should clearly demonstrate access to an appropriate patient population large enough to produce meaningful results, and if the project is a clinical trial, the trial is expected to begin within six months of the award date. If the study depends on a drug, device, compound, or other materials, the application is expected to show documented availability and access to those resources for the full proposed study period.
There are also compliance and transparency expectations for funded work. Trials supported by this award must post the IRB-approved informed consent form used for enrollment on a publicly available federal website, consistent with federal human subjects protection requirements described in 32 CFR 219. This aligns with broader federal expectations around ethical conduct, documentation, and public accountability in human subjects research.
From an administrative standpoint, this is a discretionary DoD opportunity under the U.S. Army Medical Research Acquisition Activity (USAMRAA), within the Congressionally Directed Medical Research Programs (CDMRP) ecosystem. It can be awarded as a grant or cooperative agreement, is categorized under science and technology and other research and development, and is listed under CFDA 12.420. Eligibility is described as unrestricted, meaning it is broadly open to different types of entities unless additional eligibility clarifications apply elsewhere in the full announcement. The FY22 posting listed an expected number of awards of 15, with an original application closing date of September 14, 2022. The listed award ceiling was shown as 0 in the extracted record, which typically means applicants need to consult the full announcement for specific budget limits or that ceilings may be handled in program-specific guidance rather than in that summary field.
Overall, this award is geared toward teams that already have a solid footing in clinical or clinical trial work and want to answer the next set of hard questions: how to make evidence-based TBI and psychological health approaches work in everyday settings, how to ensure they reach the people who need them, how to sustain them once implemented, and when it is appropriate to pull back from practices that do not deliver value or may cause harm.Apply for W81XWH 22 TBIPHRP PCRA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Traumatic Brain Injury and Psychological Health, Patient-Centered Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Jul 15, 2022.
- Applicants must submit their applications by Sep 14, 2022. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 15 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: DoD Traumatic Brain Injury and Psychological Health, Patient-Centered Research Award (FY22 TBIPHRP PCRA)
What is the FY22 TBIPHRP Patient-Centered Research Award (PCRA)?
The FY22 TBIPHRP PCRA (Funding Opportunity Number W81XWH-22-TBIPHRP-PCRA) is a Department of Defense (DoD) funding opportunity focused on moving proven or promising traumatic brain injury (TBI) and psychological health advances closer to real-world use. The program is designed to narrow the gap between what research shows can work and what actually gets adopted in clinics, health systems, and communities.
What is the main purpose of this award?
The central goal is practical, patient-centered evidence about how to deploy interventions, clinical practices and guidelines, tools, and even policies so they reach the right populations at the right time and place and lead to measurable patient benefit. The emphasis is on real-world effectiveness, dissemination, implementation, scale-up, sustainability, and appropriate use (including discontinuation) rather than early-stage discovery.
Is this program focused on basic science or early-stage discovery?
No. This mechanism is oriented toward implementation and real-world effectiveness research. It is intended to push advances closer to adoption in routine settings rather than supporting early-stage discovery work.
What research areas does the opportunity cover?
The opportunity covers clinical approaches relevant to TBI and psychological health, with a focus on how evidence-based interventions, tools, guidelines, and policies can be adopted and used effectively in real-world environments.
Does this award support clinical research and clinical trials?
Yes. The opportunity supports clinical research and clinical trials only, meaning the work must be grounded in human-focused research.
Are animal studies or preclinical studies allowed?
No. Preclinical studies and animal research are not allowed under this mechanism.
What types of human-focused study designs are allowed?
Applicants may propose prospective or retrospective studies involving human participants, human data or records, and/or human anatomical substances, as long as the work fits within the clinical research/clinical trial scope described in the opportunity.
Are studies that require an Exception From Informed Consent (EFIC) allowed?
No. The program explicitly does not allow studies that require an Exception From Informed Consent (EFIC), which is typically used in certain emergency research situations.
What kinds of projects are considered a good fit for this award?
Projects are expected to be patient-centered and decision-relevant, with a strong emphasis on real-world use. Examples described in the opportunity include comparative effectiveness research in routine care settings; development and testing of strategies to overcome barriers to adoption or integration; analyses of existing datasets or resources to inform practice; refinement or modification of established clinical tools for better fit; evaluation of existing tools to improve outcomes that matter to patients; and studies on how to scale, sustain, and appropriately apply clinical approaches.
What is comparative effectiveness research in the context of this award?
Comparative effectiveness research, as described here, involves weighing the benefits and harms of emerging or established interventions in routine care settings where real-world constraints and patient variability influence outcomes.
What is dissemination and implementation research as emphasized by this program?
The program is looking to build a knowledge base on how to disseminate, implement, scale up, and sustain clinical approaches for TBI and psychological health, including how to integrate them into workflows and adapt them appropriately for target populations and settings.
Does the program support research on stopping the use of ineffective or low-value practices?
Yes. The scope includes "de-implementation" research, which studies when and why it is appropriate to stop or reduce interventions, tools, or guidelines that are ineffective, unproven, low-value, or potentially harmful.
Is Community-Based Participatory Research (CBPR) required?
Yes. The program mandates the use of Community-Based Participatory Research (CBPR) approaches in both the development and execution of the proposed clinical research or trial. This reflects an expectation that affected communities and stakeholders meaningfully shape the research questions, methods, and conduct of the work.
How do applicants document the required CBPR elements?
The opportunity states that CBPR elements must be documented in specific application attachments (Attachments 11 and 12).
Is preliminary data required?
Yes. Applicants must include preliminary data that directly supports the feasibility or rationale of the proposed clinical research or trial.
Do applicants need to show access to a patient population?
Where relevant, proposals should clearly demonstrate access to an appropriate patient population large enough to produce meaningful results.
If the project is a clinical trial, when is it expected to start?
If the project is a clinical trial, the trial is expected to begin within six months of the award date.
What if the study depends on a drug, device, compound, or other materials?
If the study depends on a drug, device, compound, or other materials, the application is expected to show documented availability and access to those resources for the full proposed study period.
Are there human subjects compliance or transparency requirements mentioned?
Yes. Trials supported by this award must post the IRB-approved informed consent form used for enrollment on a publicly available federal website, consistent with federal human subjects protection requirements described in 32 CFR 219.
Who administers this funding opportunity?
Administratively, this is a discretionary DoD opportunity under the U.S. Army Medical Research Acquisition Activity (USAMRAA), within the Congressionally Directed Medical Research Programs (CDMRP) ecosystem.
What type of award instrument is used?
The opportunity may be awarded as a grant or a cooperative agreement.
What is the CFDA number associated with this opportunity?
The listing is under CFDA 12.420.
What is the eligibility for this opportunity?
Eligibility is described as unrestricted, meaning it is broadly open to different types of entities unless additional eligibility clarifications apply elsewhere in the full announcement.
How many awards were expected for the FY22 posting?
The FY22 posting listed an expected number of awards of 15.
What was the application closing date shown for FY22?
The original application closing date listed was September 14, 2022.
Is there a maximum award amount (award ceiling) provided in the summary?
The extracted record showed an award ceiling of 0. This typically indicates that applicants should consult the full announcement for specific budget limits, or that ceilings may be provided through program-specific guidance rather than in the summary field.
What kinds of outcomes does the program care about?
The program emphasizes measurable patient benefit and outcomes that matter to patients, especially evidence about how to make approaches work in everyday settings and how to ensure they reach the people who need them.
What is the overall theme of the FY22 TBIPHRP PCRA?
The award is geared toward teams aiming to answer practical next-step questions: how to make evidence-based TBI and psychological health approaches work in routine care and community settings, how to implement and sustain them at scale, how to ensure appropriate use, and when it is appropriate to reduce or stop practices that do not deliver value or may cause harm.
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| DoD Traumatic Brain Injury and Psychological Health, Clinical Trial Award Apply for W81XWH 22 S TBIPH1 Funding Number: W81XWH 22 S TBIPH1 Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Traumatic Brain Injury and Psychological Health, Investigator Initiated Research Award Apply for W81XWH 22 TBIPHRP IIRA Funding Number: W81XWH 22 TBIPHRP IIRA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
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