Opportunity Information: Apply for RFA CA 20 011
This funding opportunity, RFA-CA-20-011, is a National Cancer Institute (NCI) grant announcement that supports revision applications to active NCI-funded R01 projects. The central idea is to help currently funded cancer research teams expand or speed up the aims of their parent R01 by bringing in informatics approaches, software, platforms, or data resources that were created through the NCI Informatics Technology for Cancer Research (ITCR) Program. Rather than funding entirely new stand-alone projects, this FOA is focused on targeted, additive work that meaningfully strengthens an existing R01 by integrating ITCR-developed technologies into the parent study.
The program is designed to drive real-world adoption of ITCR tools by motivating researchers who are already running NCI R01 studies to incorporate these tools into ongoing cancer research workflows. The emphasis is on adoption, adaptation, and integration: applicants are expected to do more than simply mention an informatics tool or use it in a minimal way. The revision should show how leveraging an ITCR method or resource will directly expand the scientific scope, address new related questions, improve rigor or efficiency, or otherwise accelerate the research trajectory of the parent award. A major goal is to spur new collaborations, particularly interdisciplinary partnerships that connect cancer biologists, clinicians, and population scientists with informatics experts and ITCR tool developers, so that advanced informatics capabilities translate into measurable improvements in cancer research productivity and discovery.
This FOA uses the R01 grant mechanism and allows clinical trials, meaning proposed revision activities may include clinical trial components if they fit the scientific plan and NIH requirements. The opportunity falls under the Department of Health and Human Services, National Institutes of Health, and aligns with the broader ITCR mission of enabling cancer research through innovative informatics technology. In practice, projects responsive to this FOA would typically demonstrate a strong match between the needs of the parent R01 and the capabilities of a specific ITCR-developed tool or resource, along with a clear plan for implementation, evaluation, and dissemination of lessons learned to the relevant research community.
Funding details indicate an award ceiling of $300,000, with an expectation of about four awards. This suggests a competitive, selective program aimed at a small number of high-impact revisions that can serve as strong examples of ITCR technology being applied in real cancer research settings. The original closing date was November 18, 2020, and the creation date was January 23, 2020, which frames it as a time-limited solicitation rather than an open-ended parent announcement.
Eligibility is broad and includes many organization types commonly eligible for NIH grants: public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3) organizations), for-profit organizations (other than small businesses) and small businesses, and multiple levels of government entities (state, county, city/township, special districts), as well as federally recognized tribal governments and other tribal organizations. Independent school districts and public housing authorities/Indian housing authorities are also listed. Overall, this breadth reflects NIH norms, but the practical requirement that the applicant already hold an active NCI R01 that can accept a revision effectively narrows the pool to currently funded NCI R01 awardees proposing an appropriate expansion tied to ITCR outputs.
In summary, this FOA is meant to catalyze the use of proven, ITCR-funded informatics technologies within active NCI R01 cancer research projects by providing supplemental revision funding. The expected outcome is faster progress and broader impact from existing NCI investments, achieved through interdisciplinary collaboration and the concrete integration of advanced informatics tools into cancer research studies and, where appropriate, clinical trial-related research activities.Apply for RFA CA 20 011
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Revision Applications to Support the Application of Informatics Technology for Cancer Research (R01 Clinical Trials Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.396.
- This funding opportunity was created on Jan 23, 2020.
- Applicants must submit their applications by Nov 18, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Frequently Asked Questions (FAQs) - NCI RFA-CA-20-011 (ITCR Technology Integration Revisions to Active NCI R01s)
1) What is RFA-CA-20-011?
RFA-CA-20-011 is a National Cancer Institute (NCI) funding opportunity announcement that supports revision applications to currently active NCI-funded R01 projects. The purpose is to help existing cancer research teams expand or accelerate the scientific aims of their parent R01 by integrating informatics approaches, software, platforms, or data resources that were developed through the NCI Informatics Technology for Cancer Research (ITCR) Program.
2) What is the main goal of this funding opportunity?
The main goal is to drive real-world adoption of ITCR-developed informatics tools and resources within ongoing NCI R01 cancer research projects. The FOA is designed to catalyze meaningful integration so that advanced informatics capabilities translate into measurable improvements in cancer research productivity, rigor, efficiency, and discovery.
3) Is this opportunity meant to fund brand-new, stand-alone projects?
No. This FOA is focused on targeted, additive work through a revision application to an active NCI-funded R01. It is intended to strengthen and extend an existing parent award rather than create an entirely new, independent project.
4) What kinds of technologies or resources are expected to be used in the revision?
The revision is expected to leverage informatics approaches, software, platforms, or data resources created through the NCI Informatics Technology for Cancer Research (ITCR) Program. A responsive application typically shows a strong match between the needs of the parent R01 and the capabilities of a specific ITCR-developed tool or resource.
5) What does NCI mean by adoption, adaptation, and integration in this FOA?
Applicants are expected to do more than minimally reference an informatics tool. The revision should demonstrate concrete use of an ITCR-developed technology within the parent study workflow. The work should show how the tool will be implemented and used in practice to expand scope, address new related questions, improve rigor or efficiency, or accelerate the trajectory of the parent R01.
6) What are examples of the types of improvements the revision should enable?
Based on the FOA description, the revision should clearly explain how using an ITCR method or resource will directly strengthen the parent R01, for example by expanding the scientific scope, enabling investigation of new related questions, improving rigor, improving efficiency, or accelerating progress toward the project goals.
7) Are collaborations encouraged under this FOA?
Yes. A major goal is to spur new collaborations, especially interdisciplinary partnerships that connect cancer biologists, clinicians, and population scientists with informatics experts and ITCR tool developers. The intention is to help ensure that the ITCR-developed technologies are implemented effectively in real cancer research settings.
8) What grant mechanism does this FOA use?
This FOA uses the R01 grant mechanism, but specifically for revision applications to active NCI-funded R01 awards.
9) Are clinical trials allowed as part of the revision activities?
Yes. The FOA allows clinical trials, meaning the proposed revision activities may include clinical trial components if they align with the scientific plan and meet NIH requirements.
10) Who is the sponsoring agency for this opportunity?
The opportunity is under the U.S. Department of Health and Human Services, National Institutes of Health (NIH), specifically the National Cancer Institute (NCI). It aligns with the broader ITCR mission of enabling cancer research through innovative informatics technology.
11) What is the expected award size and how many awards are anticipated?
The funding details indicate an award ceiling of $300,000, with an expectation of about four awards. This suggests a competitive and selective program focused on a small number of high-impact revisions.
12) What does the award ceiling of $300,000 mean in practice?
Based on the information provided, the FOA includes a maximum funding level (ceiling) of $300,000 per award. Applicants should plan proposed revision activities within that limit.
13) When was this funding opportunity created and when did it close?
The creation date was January 23, 2020, and the original closing date was November 18, 2020. This frames the announcement as a time-limited solicitation rather than an open-ended opportunity.
14) What is the practical eligibility requirement beyond organizational eligibility?
While many organization types may be eligible for NIH grants, this FOA is specifically for revision applications to active NCI-funded R01 projects. Practically, that means the applicant must already hold an active NCI R01 award that can accept a revision and is suitable for the proposed ITCR technology integration.
15) What organizations are eligible to apply (as listed in the opportunity description)?
Eligibility is broad and includes: public and private institutions of higher education; nonprofits (including 501(c)(3) and non-501(c)(3) organizations); for-profit organizations (other than small businesses) and small businesses; state, county, city/township, and special district governments; federally recognized tribal governments and other tribal organizations; independent school districts; and public housing authorities/Indian housing authorities.
16) Does broad organizational eligibility mean any organization can apply?
Not necessarily. Even though many organization types are listed as eligible, the FOA is intended for teams with an active NCI-funded R01 seeking a revision. That requirement effectively narrows the applicant pool to current NCI R01 awardees whose parent project can be meaningfully strengthened by integrating ITCR-developed technologies.
17) What makes a project "responsive" to this FOA based on the description provided?
A responsive project typically demonstrates a strong match between the scientific and operational needs of the parent R01 and a specific ITCR-developed tool or resource. It also includes a clear plan for implementation, evaluation, and dissemination of lessons learned to the relevant research community.
18) What is meant by "implementation, evaluation, and dissemination" in this context?
In the context of this FOA, applications are expected to describe how the ITCR technology will be put into use within the parent study (implementation), how its impact or performance will be assessed in the research setting (evaluation), and how insights or lessons learned will be shared with the broader community that could benefit from the experience (dissemination).
19) Why does the FOA emphasize real-world adoption of ITCR tools?
The FOA is designed to encourage research teams already conducting NCI R01-funded cancer studies to incorporate ITCR technologies into active workflows. The emphasis on adoption reflects a desire to move ITCR outputs into practical use, demonstrating measurable benefits in real cancer research settings.
20) What is the expected impact of funding these revisions?
The expected outcome is faster progress and broader impact from existing NCI investments. By integrating proven ITCR-funded informatics technologies into active NCI R01 projects, the FOA aims to strengthen ongoing research and accelerate discovery, potentially including clinical trial-related research activities when appropriate.
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| Revision Applications to Support the Application of Informatics Technology for Cancer Research (U01 Clinical Trials Optional) Apply for RFA CA 20 012 Funding Number: RFA CA 20 012 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| Revision Applications to Support the Application of Informatics Technology for Cancer Research (U24 Clinical Trial Optional) Apply for RFA CA 20 013 Funding Number: RFA CA 20 013 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
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| Strengthening Institutional Capacity to Conduct Global Cancer Research in Low- and Middle-Income Countries (D43 Clinical Trial Not Allowed) Apply for RFA CA 20 031 Funding Number: RFA CA 20 031 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
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| Emergency Awards: Exosome-based Non-traditional Technologies Towards Multi-Parametric and Integrated Approaches for SARS-CoV-2 (U18 Clinical Trial Not Allowed) Apply for RFA OD 20 018 Funding Number: RFA OD 20 018 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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| Sustained Support for Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional) Apply for RFA CA 21 016 Funding Number: RFA CA 21 016 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Revision Applications to Support the Application of Informatics Technology for Cancer Research (U01 Clinical Trials Optional) Apply for RFA CA 21 018 Funding Number: RFA CA 21 018 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| Development of Innovative Informatics Methods and Algorithms for Cancer Research and Management (R21 Clinical Trial Optional) Apply for RFA CA 21 013 Funding Number: RFA CA 21 013 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Revision Applications to Support the Application of Informatics Technology for Cancer Research (R01 Clinical Trials Optional) Apply for RFA CA 21 017 Funding Number: RFA CA 21 017 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| Revision Applications to Support the Application of Informatics Technology for Cancer Research (U24 Clinical Trial Optional) Apply for RFA CA 21 019 Funding Number: RFA CA 21 019 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| NIDA Translational Avant-Garde Award for Development of Medication to Treat Substance Use Disorders (UG3/UH3 Clinical Trial Optional) Apply for PAR 21 092 Funding Number: PAR 21 092 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
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