Opportunity Information: Apply for RFA CA 20 011

This funding opportunity, RFA-CA-20-011, is a National Cancer Institute (NCI) grant announcement that supports revision applications to active NCI-funded R01 projects. The central idea is to help currently funded cancer research teams expand or speed up the aims of their parent R01 by bringing in informatics approaches, software, platforms, or data resources that were created through the NCI Informatics Technology for Cancer Research (ITCR) Program. Rather than funding entirely new stand-alone projects, this FOA is focused on targeted, additive work that meaningfully strengthens an existing R01 by integrating ITCR-developed technologies into the parent study.

The program is designed to drive real-world adoption of ITCR tools by motivating researchers who are already running NCI R01 studies to incorporate these tools into ongoing cancer research workflows. The emphasis is on adoption, adaptation, and integration: applicants are expected to do more than simply mention an informatics tool or use it in a minimal way. The revision should show how leveraging an ITCR method or resource will directly expand the scientific scope, address new related questions, improve rigor or efficiency, or otherwise accelerate the research trajectory of the parent award. A major goal is to spur new collaborations, particularly interdisciplinary partnerships that connect cancer biologists, clinicians, and population scientists with informatics experts and ITCR tool developers, so that advanced informatics capabilities translate into measurable improvements in cancer research productivity and discovery.

This FOA uses the R01 grant mechanism and allows clinical trials, meaning proposed revision activities may include clinical trial components if they fit the scientific plan and NIH requirements. The opportunity falls under the Department of Health and Human Services, National Institutes of Health, and aligns with the broader ITCR mission of enabling cancer research through innovative informatics technology. In practice, projects responsive to this FOA would typically demonstrate a strong match between the needs of the parent R01 and the capabilities of a specific ITCR-developed tool or resource, along with a clear plan for implementation, evaluation, and dissemination of lessons learned to the relevant research community.

Funding details indicate an award ceiling of $300,000, with an expectation of about four awards. This suggests a competitive, selective program aimed at a small number of high-impact revisions that can serve as strong examples of ITCR technology being applied in real cancer research settings. The original closing date was November 18, 2020, and the creation date was January 23, 2020, which frames it as a time-limited solicitation rather than an open-ended parent announcement.

Eligibility is broad and includes many organization types commonly eligible for NIH grants: public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3) organizations), for-profit organizations (other than small businesses) and small businesses, and multiple levels of government entities (state, county, city/township, special districts), as well as federally recognized tribal governments and other tribal organizations. Independent school districts and public housing authorities/Indian housing authorities are also listed. Overall, this breadth reflects NIH norms, but the practical requirement that the applicant already hold an active NCI R01 that can accept a revision effectively narrows the pool to currently funded NCI R01 awardees proposing an appropriate expansion tied to ITCR outputs.

In summary, this FOA is meant to catalyze the use of proven, ITCR-funded informatics technologies within active NCI R01 cancer research projects by providing supplemental revision funding. The expected outcome is faster progress and broader impact from existing NCI investments, achieved through interdisciplinary collaboration and the concrete integration of advanced informatics tools into cancer research studies and, where appropriate, clinical trial-related research activities.

  • The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Revision Applications to Support the Application of Informatics Technology for Cancer Research (R01 Clinical Trials Optional)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.396.
  • This funding opportunity was created on Jan 23, 2020.
  • Applicants must submit their applications by Nov 18, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $300,000.00 in funding.
  • The number of recipients for this funding is limited to 4 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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