Single Source : NIH Blueprint for Neuroscience Research: NeuroImaging Tools and Resources Collaboratory (R24 Clinical Trial Not Allowed) | RFA EB 23 003

Opportunity Information: Apply for RFA EB 23 003

The funding opportunity titled "Single Source: NIH Blueprint for Neuroscience Research: NeuroImaging Tools and Resources Collaboratory (R24 Clinical Trial Not Allowed)" (RFA-EB-23-003) is a National Institutes of Health (NIH) discretionary grant designed to sustain and advance the NeuroImaging Tools and Resources Collaboratory. The central aim is to enable collaborative research in neuroimaging informatics, meaning the work is focused on building, improving, integrating, and supporting shared tools, platforms, data resources, and related infrastructure that help the neuroscience community collect, manage, analyze, standardize, and share neuroimaging data. The mechanism is an R24, and the announcement explicitly states that clinical trials are not allowed under this award, which signals that the funded work should concentrate on resource development, coordination, and informatics-focused research support rather than interventional clinical testing.

A key feature of this NOFO is that it is effectively a limited competition. Eligibility is restricted primarily to the U24 awardees and subawardees from the earlier funding announcement RFA-EB-16-002. In other words, the applicant pool is largely confined to the teams already funded under that prior U24 initiative, reflecting NIHs intent to continue or transition an existing collaboratory effort rather than launch an entirely new one. Even though the broader eligibility language lists many organization types, the limiting condition tied to the prior U24 awards is the practical gatekeeper for who can actually compete.

Within the formal eligibility categories, NIH includes a wide range of domestic entities: state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits both with and without 501(c)(3) status (as long as they are not institutions of higher education in those categories); for-profit organizations other than small businesses; and small businesses. The NOFO also calls out additional institution types that NIH often highlights for inclusivity and capacity-building, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.

The foreign eligibility rules are specific. Non-domestic (non-U.S.) entities and non-domestic foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply. At the same time, "foreign components" as defined by the NIH Grants Policy Statement are allowed, meaning a U.S. applicant can include certain internationally performed elements or collaborations if they meet NIH policy definitions and are appropriately justified, even though a foreign organization cannot be the applicant.

From a funding and administrative standpoint, the opportunity is categorized under CFDA numbers 93.113, 93.121, 93.213, 93.242, 93.273, 93.279, 93.286, 93.853, 93.865, 93.866, and 93.867, reflecting NIHs multi-institute participation and the cross-cutting nature of the NIH Blueprint for Neuroscience Research. The award ceiling is listed as $700,000, indicating the maximum expected budget level under the announcement. The original application due date was July 18, 2023, and the notice was created on July 5, 2023, placing this as a time-limited call with a short window between posting and closing.

In practical terms, this NOFO is about maintaining and strengthening a collaboratory that the broader neuroscience and neuroimaging fields can rely on. The emphasis on "tools and resources" and "collaborative research in neuroimaging informatics" implies deliverables like shared software tools, pipelines, standards, data harmonization approaches, interoperability solutions, user support and documentation, community coordination, and potentially governance and dissemination activities that make neuroimaging data more usable and reproducible across studies and institutions. The "clinical trial not allowed" restriction reinforces that applicants should propose infrastructure and informatics advancement work rather than clinical intervention testing.

• The National Institutes of Health in the education, environment, health, income security and social services sector is offering a public funding opportunity titled "Single Source : NIH Blueprint for Neuroscience Research: NeuroImaging Tools and Resources Collaboratory (R24 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.213, 93.242, 93.273, 93.279, 93.286, 93.853, 93.865, 93.866, 93.867.
• This funding opportunity was created on 2023-07-05.
• Applicants must submit their applications by 2023-07-18. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $700,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA EB 23 003

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