Opportunity Information: Apply for RFA CA 19 017
The grant opportunity "Approaches to Identify and Care for Individuals with Inherited Cancer Syndromes (U01 Clinical Trial Required)" (RFA-CA-19-017) is a National Cancer Institute (NCI) cooperative agreement announcement under the U.S. Department of Health and Human Services and the NIH. It sits within the Beau Biden Cancer Moonshot initiative, a national effort designed to speed up progress in cancer research and translate that progress into real-world benefits. The central idea behind this FOA is practical and prevention-focused: more people who carry inherited genetic risks for cancer need to be identified, connected to the right follow-up care, and supported over time so they actually receive evidence-based screening, prevention, and early detection services.
The program is framed around a specific Cancer Moonshot Blue Ribbon Panel scientific priority (Recommendation G), which emphasized strengthening early detection, genetic testing, genetic counseling, and the broader knowledge base around mechanisms and biomarkers related to cancer development. In other words, the FOA is not simply asking for more genetic discoveries in the lab. It is asking applicants to build and test workable approaches that improve how healthcare systems find individuals and families with hereditary cancer syndromes, confirm risk through appropriate genetic evaluation, and then ensure those individuals receive recommended surveillance and preventive care. The emphasis on "demonstration projects" signals that NCI is looking for practical models that can be implemented, evaluated, and potentially scaled, with outcomes that matter to patients and health systems, such as lives saved, quality of life improvements, and reduced healthcare costs through prevention and earlier detection.
The announcement specifically invites applications using a multi-Program Director/Principal Investigator structure, reflecting how complex hereditary cancer care is across real clinical settings. These projects are expected to bring together the expertise needed to solve problems that often span multiple domains: oncology, primary care, genetics, genetic counseling, public health, health services research, informatics, and community engagement. The goal is to identify and validate best practices for both case ascertainment (finding the right people, including those who may not realize they are at high risk) and follow-up care (making sure identified individuals actually get guideline-based management, such as appropriate screening intervals, risk-reducing options when indicated, and cascade testing or outreach to family members where appropriate).
A key structural feature is that this is a cooperative agreement (U01), meaning awardees should expect substantial scientific and programmatic involvement from NIH/NCI staff compared with a typical investigator-initiated grant. Cooperative agreements are commonly used when the funder anticipates that close coordination, shared standards, or active oversight will help align projects with program goals, promote harmonization across sites, and generate results that are comparable and useful beyond a single institution. The title also indicates "Clinical Trial Required," which generally means applicants must include a clinical trial component as defined by NIH, such as prospective testing of an intervention or strategy related to identifying at-risk individuals and improving their care pathways, with measurable outcomes.
In terms of who can apply, eligibility is broad and includes many types of organizations positioned to influence hereditary cancer identification and care. Eligible applicants include state, county, and local governments; tribal governments and tribal organizations; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; public housing authorities/Indian housing authorities; for-profit organizations (other than small businesses) as well as small businesses; and other entities as described in the FOA. This wide eligibility list aligns with the reality that improving identification and follow-up for inherited cancer risk may require partnerships that extend beyond academic medical centers, including public health infrastructure, community-based health systems, payers, and organizations serving populations that have historically had limited access to genetic services.
Administratively, the FOA was created on August 10, 2018, with an original closing date of January 9, 2019. It is listed under CFDA numbers 93.393 and 93.399, which are commonly associated with NCI research support mechanisms. The announcement anticipated making about four awards. The award ceiling is listed as 0, which typically indicates that a specific cap was not provided in the summary field and that applicants should rely on the detailed FOA instructions or NCI guidance for budget expectations and project scope.
Overall, the opportunity is best understood as an implementation and care-delivery improvement initiative focused on hereditary cancer syndromes. It prioritizes improving real-world pathways: identifying individuals and families at inherited risk, connecting them to genetic evaluation and counseling as appropriate, and ensuring that evidence-based prevention and early detection practices are actually delivered and sustained. The bigger-picture aim is to demonstrate approaches that not only improve clinical outcomes for high-risk individuals, but also create replicable models that health systems can adopt to reduce preventable cancer burden and associated costs.Apply for RFA CA 19 017
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Approaches to Identify and Care for Individuals with Inherited Cancer Syndromes (U01 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.399.
- This funding opportunity was created on Aug 10, 2018.
- Applicants must submit their applications by Jan 09, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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| HIV/AIDS High Priority Drug Abuse Research (R01 Clinical Trial Optional) Apply for PAS 18 915 Funding Number: PAS 18 915 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Fusion Oncoproteins in Childhood Cancers (FusOnC2) Consortium (U54 Clinical Trial Not Allowed) Apply for RFA CA 19 016 Funding Number: RFA CA 19 016 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,600,000 |
| Administrative Supplements to Cancer Center Support Grants to Strengthen the Research, Training, and Outreach Capacity of the Geographic Management of Cancer Health Disparities Program (Admin Suppl - Clinical Trial Not Allowed) Apply for PA 18 934 Funding Number: PA 18 934 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| The National Drug Abuse Treatment Clinical Trials Network (UG1 Clinical Trial Optional) Apply for RFA DA 19 008 Funding Number: RFA DA 19 008 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| NLM Grants for Scholarly Works in Biomedicine and Health (G13 Clinical Trial Not Allowed) Apply for PAR 19 032 Funding Number: PAR 19 032 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $50,000 |
| Administrative Supplements to Cancer Center Support Grants to Strengthen NCI-Supported Community Outreach Capacity through Community Health Educators of the National Outreach Network (Admin Suppl Clinical Trial Not Allowed) Apply for PA 19 035 Funding Number: PA 19 035 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $125,000 |
| Immuno-Oncology Translation Network (IOTN): Immuno-engineering to Improve Immunotherapy (i3) Centers (U54 Clinical Trial Not Allowed) Apply for RFA CA 19 013 Funding Number: RFA CA 19 013 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $900,000 |
| HEAL Initiative: Justice Community Opioid Innovation Network (JCOIN) Coordination and Translation Center (U2C Clinical Trial Optional) Apply for RFA DA 19 024 Funding Number: RFA DA 19 024 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $2,500,000 |
| HEAL Initiative: Justice Community Opioid Innovation Network (JCOIN) Methodology and Advanced Analytics Resource Center (U2C Clinical Trial Not Allowed) Apply for RFA DA 19 023 Funding Number: RFA DA 19 023 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $2,500,000 |
| NCI Pathway to Independence Award for Outstanding Early Stage Postdoctoral Researchers (K99/R00 - Independent Clinical Trial Not Allowed) Apply for RFA CA 19 029 Funding Number: RFA CA 19 029 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Pathway to Independence Award for Outstanding Early Stage Postdoctoral Researchers (K99/R00 - Independent Clinical Trial Required) Apply for RFA CA 19 030 Funding Number: RFA CA 19 030 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Advanced Development and Validation of Emerging Biospecimen Science Technologies for Basic and Clinical Cancer Research (R33 Clinical Trials Not Allowed) Apply for RFA CA 19 022 Funding Number: RFA CA 19 022 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Innovative Biospecimen Science Technologies for Basic and Clinical Cancer Research (R21 Clinical Trials Not Allowed) Apply for RFA CA 19 021 Funding Number: RFA CA 19 021 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Advanced Development and Validation of Emerging Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R33 Clinical Trials Not Allowed) Apply for RFA CA 19 020 Funding Number: RFA CA 19 020 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Innovative Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R21 Clinical Trials Not Allowed) Apply for RFA CA 19 019 Funding Number: RFA CA 19 019 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (P50 Clinical Trial Optional) Apply for RFA CA 19 027 Funding Number: RFA CA 19 027 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (U54 Clinical Trials Optional) Apply for RFA CA 19 025 Funding Number: RFA CA 19 025 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (P01 Clinical Trial Optional) Apply for RFA CA 19 026 Funding Number: RFA CA 19 026 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (R01 Clinical Trial Optional) Apply for RFA CA 19 023 Funding Number: RFA CA 19 023 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revisions for Incorporation of Novel NCI- Supported Technology to Accelerate Cancer Research (U01 Clinical Trial Optional) Apply for RFA CA 19 024 Funding Number: RFA CA 19 024 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
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