Opportunity Information: Apply for RFA AA 23 004
The Comprehensive Alcohol-HIV/AIDS Research Center (P60 Clinical Trial Optional) funding opportunity (RFA-AA-23-004) is a National Institutes of Health (NIH) center-grant program led by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). It is designed to support high-impact, coordinated research centers focused specifically on the intersection of alcohol use and HIV/AIDS. The overall aim is to generate findings that meaningfully improve HIV prevention, treatment outcomes, and long-term health for people affected by HIV, particularly where alcohol use (and related factors) makes HIV control more difficult. While clinical trials are optional under this announcement, the emphasis is on translational work that can move insights from mechanisms and real-world patterns into practical strategies, interventions, and implementation approaches.
A central theme of the announcement is that alcohol use is not being treated as a side issue, but as a major, modifiable driver that can influence nearly every stage of the HIV continuum. NIAAA is seeking research that clarifies how alcohol use, alcohol use disorder, and alcohol-related behaviors increase HIV acquisition risk, interfere with prevention tools (such as PrEP uptake and adherence), reduce treatment effectiveness (including ART adherence and viral suppression), and worsen HIV-related comorbidities. The FOA also explicitly highlights that alcohol-related impacts often occur alongside other substance use, mental health conditions, and medication or pharmacological complications. In practice, this means proposed centers are expected to address complex, overlapping realities that patients and communities face, rather than isolating alcohol from co-occurring challenges that can compound HIV risk and worsen clinical outcomes.
The opportunity is strongly aligned with federal HIV research and policy priorities, particularly the NIH Office of AIDS Research (OAR) Strategic Plan for HIV and HIV-Related Research (FY2021-FY2025) and the National HIV/AIDS Strategy (2022-2025). By referencing these frameworks, the announcement signals that responsive applications should be clearly connected to nationally prioritized HIV goals, including the broader push to end the HIV epidemic and to improve outcomes among populations disproportionately affected by HIV and substance use. A key point is that NIAAA is encouraging research that can help close gaps for substance users, including people whose alcohol use makes engagement in prevention or sustained treatment more difficult.
Structurally, this is a discretionary grant program in the health funding category (CFDA 93.273) using a center-style grant mechanism (P60). While the announcement text provided does not lay out the internal cores or project components, the intent of a research center grant is typically to support an integrated set of complementary projects under a unifying theme, leveraging shared resources, expertise, and infrastructure to produce results that would be difficult to achieve through isolated individual projects. In other words, the program is looking for a hub that can drive a coherent research agenda on alcohol and HIV/AIDS, rather than a single stand-alone study.
The eligible applicant pool is broad and includes many types of U.S.-based organizations: state, county, and local governments; special districts; independent school districts; public and private institutions of higher education; public housing authorities/Indian housing authorities; federally recognized tribal governments; other tribal organizations; nonprofits (with or without 501(c)(3) status); for-profit organizations other than small businesses; small businesses; and other eligible entities. The FOA also calls out additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. On the foreign eligibility side, non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply as the applicant organization. However, non-domestic components of U.S. organizations are eligible, and foreign components (as NIH defines them) are allowed, which can matter for centers that need international field sites, collaborations, or specialized expertise while keeping the prime applicant organization U.S.-based.
Key dates and funding details included in the source information are that the opportunity was created on 2023-10-17, with an original closing date of 2024-04-18. The listed award ceiling is $1,200,000, indicating the maximum expected funding level per award under the ceiling specified in the opportunity record. The entry also notes “ExpectedAwards:” but does not provide a number in the excerpt, so applicants would need to consult the full FOA for the anticipated number of awards and any additional budget structure, project period expectations, or required center components.
In practical terms, the FOA is looking for research centers that can tackle the most consequential barriers to controlling and ultimately ending the HIV/AIDS pandemic where alcohol plays a meaningful role. Competitive applications will likely be those that clearly define the real-world HIV problem being addressed, explain how alcohol use and its related complications drive that problem, and propose a coordinated, translational research plan that can produce actionable outcomes for prevention, care, and comorbidity management in affected communities.Apply for RFA AA 23 004
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Comprehensive Alcohol-HIV/AIDS Research Center (P60 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273.
- This funding opportunity was created on 2023-10-17.
- Applicants must submit their applications by 2024-04-18. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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