Opportunity Information: Apply for RFA IP 17 001
The grant opportunity "Household Transmission of Influenza Viruses in the Community" (Funding Opportunity Number RFA IP 17 001) is a CDC cooperative agreement aimed at improving understanding of how influenza spreads within households, which are estimated to account for up to about 30 percent of influenza virus transmission. The core public health motivation is that households function as high-intensity, close-contact settings where infections can spread quickly, and studying them provides a practical way to measure both symptomatic illness and the broader clinical spectrum of influenza infection, including milder or less obvious cases that still contribute to transmission.
The project’s main activity is to identify and enroll households in which at least one member has a confirmed influenza infection (often referred to as the index case) and then actively follow the other household members (household contacts) for up to two weeks. During this follow-up window, the study would track whether additional household members become infected, allowing investigators to estimate the secondary infection risk (sometimes described as the household secondary attack rate). In addition to producing a basic estimate of how often influenza spreads to close contacts at home, the study is designed to examine what factors are associated with higher or lower risk of transmission and infection. These factors commonly include characteristics of the infected person and contacts (such as age and underlying health), household structure and crowding, patterns of interaction within the home, timing of exposure, and behaviors that might reduce spread.
A major secondary aim is to estimate how effective seasonal influenza vaccination is at preventing influenza infection in the setting of close, prolonged exposure. Instead of measuring vaccine performance only in the general community, this household design focuses on exposure to a known, confirmed case, which helps answer a more practical question for prevention planning: how well vaccination protects people when they are most likely to encounter influenza, such as when a family member brings it home. Results from this type of work can inform public health guidance on vaccination strategies, post-exposure practices, and the potential value of additional interventions in households.
The opportunity is offered by the Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), and uses a cooperative agreement funding mechanism, which typically indicates substantial scientific or programmatic involvement by the agency during the project period. It falls under the health activity category and is associated with CFDA number 93.185. The maximum award amount listed is $500,000, and CDC anticipated making about three awards under this announcement.
Eligibility is broad and includes various government entities (state, county, city/township, special districts), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, federally recognized tribal governments and other tribal organizations, public housing authorities/Indian housing authorities, nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions in those categories), for-profit organizations other than small businesses, and small businesses. The announcement was created on November 16, 2016, with an original application closing date of March 1, 2017, and it specifies that electronic submissions were due by 5:00 p.m. ET on the deadline date.
Overall, the intended impact is to generate evidence that strengthens prevention and control of seasonal influenza by clarifying how transmission occurs in one of the most common real-world settings for spread. Just as importantly, these household transmission measurements and vaccine-effectiveness estimates are positioned as part of preparedness planning, helping public health agencies respond more effectively if a future influenza pandemic emerges by providing baseline understanding of transmission dynamics, risk factors, and the protective value of vaccination under close-contact conditions.Apply for RFA IP 17 001
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Household Transmission of Influenza Viruses in the Community" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.185.
- This funding opportunity was created on Nov 16, 2016.
- Applicants must submit their applications by Mar 01, 2017 Electronically submitted applications must be submitted no later than 500 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses.
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FAQs: Household Transmission of Influenza Viruses in the Community (RFA IP 17 001)
What is the name and funding opportunity number for this grant?
The opportunity is titled Household Transmission of Influenza Viruses in the Community. The Funding Opportunity Number is RFA IP 17 001.
Which federal agency is offering this opportunity?
This opportunity is offered by the Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC).
What type of funding mechanism is used?
The award is a cooperative agreement, which typically means CDC expects to have substantial scientific or programmatic involvement during the project period.
What is the public health purpose of this project?
The project is intended to improve understanding of how influenza spreads within households. Households are described as high-intensity, close-contact environments and are estimated to account for up to about 30 percent of influenza virus transmission. Studying households also helps capture both symptomatic illness and the broader clinical spectrum of infection, including milder or less obvious cases that may still contribute to spread.
What are the main activities expected under this opportunity?
The central activity is to identify and enroll households where at least one member has a confirmed influenza infection (the “index case”), then actively follow other household members (household contacts) for up to two weeks to see whether additional infections occur.
Who is the “index case” in the household study design?
The index case is the household member with a confirmed influenza infection whose illness triggers household enrollment and follow-up of other members.
Who are “household contacts” in this study?
Household contacts are the other members of the enrolled household who are followed after identification of the index case to assess whether they become infected.
How long are household contacts followed?
Household contacts are followed for up to two weeks after the index case is identified and the household is enrolled.
What outcome is the study designed to estimate related to transmission?
The study is designed to estimate the secondary infection risk in households (often described as the household secondary attack rate) by tracking whether influenza spreads from the index case to other household members during the follow-up period.
What kinds of risk factors does the project aim to examine?
Beyond estimating how often transmission occurs, the project is designed to examine factors associated with higher or lower risk of transmission and infection. Examples noted include:
- Characteristics of infected persons and contacts (such as age and underlying health)
- Household structure and crowding
- Patterns of interaction within the home
- Timing of exposure
- Behaviors that might reduce spread
Is vaccine effectiveness part of the project?
Yes. A major secondary aim is to estimate how effective seasonal influenza vaccination is at preventing influenza infection in a setting of close, prolonged exposure (i.e., within households after a confirmed case is identified).
How is vaccine effectiveness assessed differently in this household design?
Instead of assessing vaccine performance only in the general community, this approach focuses on vaccine protection when contacts have a known exposure to a confirmed household case. That design is intended to answer how well vaccination protects people in a practical, high-likelihood exposure scenario, such as when a family member brings influenza home.
How can results from this work be used for public health decision-making?
The work is positioned to inform public health guidance and planning, including vaccination strategies, post-exposure practices, and the potential value of additional interventions in households. It is also framed as supporting preparedness planning by providing baseline understanding of transmission dynamics, risk factors, and vaccine protection under close-contact conditions.
How does this opportunity relate to pandemic preparedness?
The intended impact includes improving the ability of public health agencies to respond if a future influenza pandemic emerges by providing baseline evidence on household transmission dynamics, factors that influence spread, and the protective value of vaccination during close-contact exposures.
What is the activity category for this funding opportunity?
The opportunity falls under the health activity category.
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA 93.185.
What is the maximum award amount?
The maximum award amount listed is $500,000.
How many awards did CDC anticipate making?
CDC anticipated making about three awards under this announcement.
Who is eligible to apply?
Eligibility is broad and includes the following types of organizations:
- Various government entities (state, county, city/township, special districts)
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized tribal governments and other tribal organizations
- Public housing authorities/Indian housing authorities
- Nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions in those categories)
- For-profit organizations other than small businesses
- Small businesses
When was the announcement created?
The announcement was created on November 16, 2016.
What was the original application closing date?
The original application closing date was March 1, 2017.
What was the submission method and deadline time?
The announcement specifies that electronic submissions were due by 5:00 p.m. ET on the deadline date.
Why focus on households rather than only community-level influenza spread?
Households are described as a practical, real-world setting where close contact can lead to rapid spread. This design also helps capture infections across the full clinical spectrum (including milder cases) and supports measurement of transmission to close contacts over a defined follow-up period.
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