Opportunity Information: Apply for RFA DK 18 515
This funding opportunity, RFA-DK-18-515, is a limited competition cooperative agreement (U24; clinical trial not allowed) from the National Institutes of Health to continue the work of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Tissue and Technology Core (TATC). The MAPP Network is focused on urologic chronic pelvic pain syndrome (UCPPS), an umbrella term that includes interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The larger scientific goal of the MAPP program is to generate clearer, evidence-based insights into the biology and mechanisms of UCPPS, how symptoms and patient characteristics change over time (natural history), how the condition can be subdivided into meaningful clinical phenotypes, and what risk factors may influence onset or persistence. That knowledge is intended to create a stronger foundation for future intervention studies and, ultimately, better clinical management for patients living with chronic pelvic pain.
The specific purpose of this FOA is to support an additional three-year project period for the existing, current MAPP Network TATC. In other words, it is not an open competition for new teams to start a new core; it is designed to extend the ongoing infrastructure and capabilities already embedded in the MAPP Network. Over this extension period, the network will continue collecting longitudinal phenotypic (clinical and symptom) data and biological samples from participants already enrolled in the Trans-MAPP Symptoms Patterns Study. The continued follow-up and ongoing biospecimen collection are meant to preserve and expand the value of the established cohort, enabling the network to carry out highly collaborative, integrated analyses across sites and cores and to identify new patterns or signals that shed light on UCPPS.
The opportunity sits within an established multicenter structure that includes nine Discovery Sites, a Data Coordination Core (DCC), and the Tissue and Technology Core (TATC). The TATC role, as implied by its name and placement in the network, centers on the biospecimen and technology-enabled aspects of the research enterprise, supporting standardized handling and use of biological samples as well as technology platforms and methods that help make cross-site, cross-dataset analyses feasible and comparable. Because this is a cooperative agreement, NIH is expected to have substantial involvement in coordinating or guiding certain aspects of the program in partnership with the awardee, which typically emphasizes teamwork, shared governance, and alignment with network-wide milestones.
Eligibility is restricted. The FOA invites an application from the current MAPP Network TATC, reflecting the “limited competition” design. The listed eligible applicant type includes public and state-controlled institutions of higher education, but the practical effect of the announcement is that only the existing TATC leadership organization is positioned to apply under this continuation framework. Foreign institutions (non-U.S. entities) are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply. At the same time, foreign components, as defined under NIH policy, are allowed, meaning certain collaborations or project elements occurring outside the U.S. may be permissible if they meet NIH’s definition and requirements, even though a foreign institution cannot be the applicant organization.
Administratively, the program is categorized as discretionary funding and uses the cooperative agreement funding instrument. The activity area is health-related (listed under Food and Nutrition, Health) and carries CFDA number 93.847. The original closing date for the opportunity was November 14, 2018, and it was created on September 14, 2018. The announcement does not provide an award ceiling or expected number of awards in the provided excerpt, but the structure and intent indicate support for a single continuation award tied to the ongoing MAPP Network core operations rather than multiple new awards.Apply for RFA DK 18 515
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Limited Competition for the Continuation of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Tissue and Technology Core (TATC) (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2018-09-14.
- Applicants must submit their applications by 2018-11-14. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education.
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Frequently Asked Questions (FAQs) - RFA-DK-18-515
What is RFA-DK-18-515?
RFA-DK-18-515 is a National Institutes of Health (NIH) funding opportunity announcement for a limited competition cooperative agreement (U24; clinical trial not allowed). It is intended to continue the work of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Tissue and Technology Core (TATC).
What type of funding mechanism is used for this opportunity?
This opportunity uses a cooperative agreement funding instrument (U24). As a cooperative agreement, NIH is expected to have substantial involvement in coordination and/or guidance in partnership with the awardee.
Are clinical trials allowed under this FOA?
No. The opportunity is listed as "clinical trial not allowed."
What is the purpose of this FOA?
The purpose of this FOA is to support an additional three-year project period for the existing, current MAPP Network Tissue and Technology Core (TATC). It is designed to extend the ongoing infrastructure and capabilities already embedded in the MAPP Network, rather than to start a new core or recruit new teams.
Is this an open competition for new applicants?
No. This is a limited competition. The FOA invites an application from the current MAPP Network TATC and is structured as a continuation framework for the existing core.
What is the MAPP Research Network?
The MAPP Research Network is a multicenter research program focused on urologic chronic pelvic pain syndrome (UCPPS). The network structure includes nine Discovery Sites, a Data Coordination Core (DCC), and the Tissue and Technology Core (TATC).
What conditions are included under UCPPS in this program?
Urologic chronic pelvic pain syndrome (UCPPS) is described as an umbrella term that includes interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).
What are the broader scientific goals of the MAPP program?
The larger scientific goal is to generate clearer, evidence-based insights into the biology and mechanisms of UCPPS, understand how symptoms and patient characteristics change over time (natural history), identify meaningful clinical phenotypes (subgroups), and determine risk factors that may influence onset or persistence. This knowledge is intended to support future intervention studies and improve clinical management over time.
What work will continue during the three-year extension period?
During the extension period, the network will continue collecting longitudinal phenotypic (clinical and symptom) data and biological samples from participants already enrolled in the Trans-MAPP Symptoms Patterns Study. The continued follow-up and biospecimen collection are intended to preserve and expand the value of the established cohort.
Why does this FOA emphasize continued follow-up and biospecimen collection?
Continuing follow-up and biospecimen collection helps preserve the scientific value of the established participant cohort and supports collaborative, integrated analyses across sites and cores. This can enable the identification of new patterns or signals relevant to UCPPS.
What is the role of the Tissue and Technology Core (TATC) in the MAPP Network?
The TATC supports the biospecimen and technology-enabled aspects of the network, including standardized handling and use of biological samples and the technology platforms and methods that help make cross-site and cross-dataset analyses feasible and comparable.
How does the cooperative agreement structure affect how the project is run?
Because it is a cooperative agreement, the NIH is expected to be substantially involved in coordinating or guiding certain aspects of the program in partnership with the awardee. This typically emphasizes teamwork, shared governance, and alignment with network-wide milestones.
Who is eligible to apply?
Eligibility is restricted. The FOA invites an application from the current MAPP Network TATC. While the listed eligible applicant type includes public and state-controlled institutions of higher education, the practical effect described is that only the existing TATC leadership organization is positioned to apply under this continuation framework.
Are foreign (non-U.S.) institutions eligible to apply as the applicant organization?
No. Foreign institutions (non-U.S. entities) are not eligible to apply under this opportunity.
Are non-domestic components of U.S. organizations eligible to apply?
No. Non-domestic components of U.S. organizations are not eligible to apply.
Are foreign components allowed at all under this FOA?
Yes. Foreign components, as defined under NIH policy, are allowed. This means certain collaborations or project elements occurring outside the U.S. may be permissible if they meet NIH's definition and requirements, even though a foreign institution cannot serve as the applicant organization.
What is the activity area or topic area for this funding opportunity?
The activity area is health-related and is listed under Food and Nutrition, Health.
What is the CFDA number associated with this opportunity?
The CFDA number listed for this opportunity is 93.847.
Is this considered discretionary funding?
Yes. The program is categorized as discretionary funding.
What is the expected project period supported by this FOA?
The FOA supports an additional three-year project period for the existing MAPP Network TATC.
How many awards will be made, and what is the award ceiling?
The provided excerpt does not state an award ceiling or expected number of awards. However, the structure and intent indicate support for a single continuation award tied to ongoing MAPP Network core operations rather than multiple new awards.
When was this opportunity created, and what was the closing date?
The opportunity was created on September 14, 2018, and the original closing date was November 14, 2018.
What study cohort is referenced in the continuation activities?
The continuation activities reference participants already enrolled in the Trans-MAPP Symptoms Patterns Study.
What kinds of data will continue to be collected?
The network will continue collecting longitudinal phenotypic data, described as clinical and symptom data, along with biological samples.
What is the relationship between the Discovery Sites, DCC, and TATC?
The MAPP Network operates as a multicenter structure made up of nine Discovery Sites, a Data Coordination Core (DCC), and the Tissue and Technology Core (TATC). The TATC focuses on biospecimens and enabling technologies, while the DCC is identified as a core component of the network alongside the Discovery Sites and TATC.
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